For the 2026 school year, there are 3 public high schools serving 637 students in Mississippi County, MO.
The top-ranked public high schools in Mississippi County, MO are East Prairie High School and Charleston High School. Overall testing rank is based on a school's combined math and reading proficiency test score ranking.
Mississippi County, MO public high schools have an average math proficiency score of 15% (versus the Missouri public high school average of 36%), and reading proficiency score of 39% (versus the 51% statewide average). High schools in Mississippi County have an average ranking of 1/10, which is in the bottom 50% of Missouri public high schools.
Mississippi County, MO public high school have a Graduation Rate of 91%, which is more than the Missouri average of 89%.
The school with highest graduation rate is East Prairie High School, with 90-94% graduation rate. Read more about public school graduation rate statistics in Missouri or national school graduation rate statistics.
Minority enrollment is 43% of the student body (majority Black), which is more than the Missouri public high school average of 30% (majority Black).
Best Public High Schools in Mississippi County (2026)
School
(Math and Reading Proficiency)
(Math and Reading Proficiency)
Location
Quick Facts
Rank: #11.
East Prairie High School
(Math: 20-29% | Reading: 40-44%)
Rank:
Rank:
4/
Bottom 50%10
304 E Walnut
East Prairie, MO 63845
(573) 649-3564
East Prairie, MO 63845
(573) 649-3564
Gr: 9-12 | 306 students Student-teacher ratio: 13:1 Minority enrollment: 12%
Rank: #22.
Charleston High School
(Math: 10-14% | Reading: 30-39%)
Rank:
Rank:
2/
Bottom 50%10
606 S. Thorn St
Charleston, MO 63834
(573) 683-3761
Charleston, MO 63834
(573) 683-3761
Gr: 7-12 | 331 students Student-teacher ratio: 12:1 Minority enrollment: 72%
Rank: n/an/a
Southeast Correctional Center
Alternative School
300 E Pedro Simmons Dr
Charleston, MO 63834
(573) 683-4409
Charleston, MO 63834
(573) 683-4409
Gr: 7-12
Mississippi County Public Schools (Closed)
School
Location
Quick Facts
510 Wilkinson
East Prairie, MO 63845
(573) 649-3521
East Prairie, MO 63845
(573) 649-3521
Gr: 3-6
711 E Commercial St
Charleston, MO 63834
(573) 683-3913
Charleston, MO 63834
(573) 683-3913
Gr: K | 92 students Student-teacher ratio: 12:1 Minority enrollment: 66%
210 E Washington
East Prairie, MO 63845
(573) 649-9368
East Prairie, MO 63845
(573) 649-9368
Gr: 7-8
402 Washington
East Prairie, MO 63845
(573) 649-2272
East Prairie, MO 63845
(573) 649-2272
Gr: PK-2
Frequently Asked Questions
What are the top-ranked public high schools in Mississippi County, MO?
The top-ranked public high schools in Mississippi County, MO include East Prairie High School and Charleston High School.
How many public high schools are located in Mississippi County?
3 public high schools are located in Mississippi County.
What is the racial composition of students in Mississippi County?
Mississippi County public high schools minority enrollment is 43% of the student body (majority Black), which is more than the Missouri public high schools average of 30% (majority Black).
Which public high schools in Mississippi County are often viewed compared to one another?
Popular comparisons of public high schools in Mississippi County include: Charleston High School vs. East Prairie High School, East Prairie High School vs. Charleston High School
Recent Articles
Spring Parent-Teacher Conferences: Key Questions
Spring Parent-Teacher Conferences: Questions Every Parent Should Ask to support academic growth, social development, and 2026 classroom goals.
Prepare for Spring Tests Without Anxiety
Learn how to prepare for spring standardized tests without increasing anxiety using proven strategies for families and schools.
Why Public Schools Are Launching Marketing Campaigns in 2026
Discover why public schools are launching marketing campaigns in 2026 and how enrollment shifts, school choice, and funding pressures are driving change.